4,4,5,5-Tetramethyl-2-(5-methylthiophen-2-yl)-1,3,2-dioxaborolane → 6-Fluoro-1-(1-(6-(5-methylthiophen-2-yl)pyridazin-3-yl)piperidin-4-yl)indoline

HRID 512850Notes

Reaction equation

HRID 512850 reaction equation
[CH3:1][C:2]1[S:6][C:5](B2OC(C)(C)C(C)(C)O2)=[CH:4][CH:3]=1.Cl[C:17]1[N:22]=[N:21][C:20]([N:23]2[CH2:28][CH2:27][CH:26]([N:29]3[C:37]4[C:32](=[CH:33][CH:34]=[C:35]([F:38])[CH:36]=4)[CH2:31][CH2:30]3)[CH2:25][CH2:24]2)=[CH:19][CH:18]=1>>[F:38][C:35]1[CH:36]=[C:37]2[C:32]([CH2:31][CH2:30][N:29]2[CH:26]2[CH2:27][CH2:28][N:23]([C:20]3[N:21]=[N:22][C:17]([C:5]4[S:6][C:2]([CH3:1])=[CH:3][CH:4]=4)=[CH:18][CH:19]=3)[CH2:24][CH2:25]2)=[CH:33][CH:34]=1

Participants

3

Reactant 2

HCID 118169404,4,5,5-Tetramethyl-2-(5-methylthiophen-2-yl)-1,3,2-dioxaborolaneHCID 896144661-(1-(6-Chloropyridazin-3-yl)piperidin-4-yl)-6-fluoroindoline

Product 1

HCID 763291776-Fluoro-1-(1-(6-(5-methylthiophen-2-yl)pyridazin-3-yl)piperidin-4-yl)indoline

Procedure

The title compound was prepared following the procedure as described in Example 1, Method A, STEP 4, reacting 5-methylthiophene-2-boronic acid pinacol ester and 1-(1-(6-chloropyridazin-3-yl)piperidin-4-yl)-6-fluoroindoline.

Sources & evidence

ORD record
ord-b8f9153561904d17bf858e3645dde182
Source dataset
uspto-grants-2015_08
Patent number
US09102669B2

Reaction notes

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