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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 512850Generated: October 30, 2026

4,4,5,5-Tetramethyl-2-(5-methylthiophen-2-yl)-1,3,2-dioxaborolane → 6-Fluoro-1-(1-(6-(5-methylthiophen-2-yl)pyridazin-3-yl)piperidin-4-yl)indoline

https://huagongshe.com/reaction/512850

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4,4,5,5-Tetramethyl-2-(5-methylthiophen-2-yl)-1,3,2-dioxaborolaneHCID 11816940—
Reactant1-(1-(6-Chloropyridazin-3-yl)piperidin-4-yl)-6-fluoroindolineHCID 89614466—
Product6-Fluoro-1-(1-(6-(5-methylthiophen-2-yl)pyridazin-3-yl)piperidin-4-yl)indolineHCID 76329177—

Reaction Steps

The title compound was prepared following the procedure as described in Example 1, Method A, STEP 4, reacting 5-methylthiophene-2-boronic acid pinacol ester and 1-(1-(6-chloropyridazin-3-yl)piperidin-4-yl)-6-fluoroindoline.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09102669B2
Source datasetuspto-grants-2015_08
ORD IDord-b8f9153561904d17bf858e3645dde182
Source noteuspto-grants-2015_08