Hydrochloric Acid → HCID 76329178, compound

HRID 512853Notes

Reaction equation

HRID 512853 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][N:8]2[CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)=[CH:4][CH:3]=1.Cl.Cl[C:19]1[N:24]=[N:23][C:22]([C:25]2[S:29][N:28]=[C:27]([CH3:30])[N:26]=2)=[CH:21][CH:20]=1>>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][N:8]2[CH:11]2[CH2:16][CH2:15][N:14]([C:19]3[N:24]=[N:23][C:22]([C:25]4[S:29][N:28]=[C:27]([CH3:30])[N:26]=4)=[CH:21][CH:20]=3)[CH2:13][CH2:12]2)=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 109218293-Chloro-6-(3-methyl-1,2,4-thiadiazol-5-yl)pyridazineHCID 220383846-Fluoro-1-(piperidin-4-yl)indoline

Product 1

HCID 76329178HCID 76329178, compound

Procedure

5-(6-(4-(6-Fluoroindolin-1-yl)piperidin-1-yl)pyridazin-3-yl)-3-methyl-1,2,4-thiadiazole was prepared according to the procedure as described in Example 1, Method B, STEP 2, reacting 6-fluoro-1-(piperidin-4-yl)indoline as its corresponding HCl salt and 5-(6-chloropyridazin-3-yl)-3-methyl-1,2,4-thiadiazole, prepared as in STEP 1 above.

Sources & evidence

ORD record
ord-f7455dfa024942cdba6be2d10ff7a0ad
Source dataset
uspto-grants-2015_08
Patent number
US09102669B2

Reaction notes

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