反应详情

To a solution of 1,3,3-trimethylbicyclo[2.2.1]hept-2-ylamine (5 g, 26.3 mmol) in methylene chloride (20 ml) and triethylamine (4 ml) was added chloroacetyl chloride (2.1 ml, 26.4 mmol) dropwise. The resulting solution was stirred for 12 hours, then the solvent removed under reduced pressure. The residue was partitioned between ethyl acetate and water, the organic layer washed with brine, and dried over magnesium sulfate. The ethyl acetate solution was absorbed onto silica gel, which was eluted with 10% ethyl acetate/hexane, to yield 2-chloro-N-(1,3,3-trimethylbicyclo[2,2,1]hept-2-yl)acetamide as a white solid.

1. customthe solvent removed under reduced pressure
2. customThe residue was partitioned between ethyl acetate and water
3. washthe organic layer washed with brine
4. dry with materialdried over magnesium sulfate
5. customThe ethyl acetate solution was absorbed onto silica gel, which
6. washwas eluted with 10% ethyl acetate/hexane