Hydrochloric Acid → HCID 86604847, compound

HRID 512915Notes

Reaction equation

HRID 512915 reaction equation
[N:1]([CH2:4][CH2:5][CH2:6][C:7]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[N:11]([C:12]([N:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])[CH3:15])=[O:13])[N:10]=[C:9]([C:21]2[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:22]=2[F:28])[S:8]1)=[N+]=[N-].Cl>CO.[Pt]=O>[NH2:1][CH2:4][CH2:5][CH2:6][C:7]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[N:11]([C:12]([N:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])[CH3:15])=[O:13])[N:10]=[C:9]([C:21]2[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:22]=2[F:28])[S:8]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86604845HCID 86604845, compound

Product 1

HCID 86604847HCID 86604847, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

To a solution of 2-(3-azidopropyl)-N-tert-butoxy-5-(2,5-difluorophenyl)-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide (0.032 g, 0.065 mmol) and platinum oxide (15 mg) in methanol (3 mL) was added HCl (5.3 M solution in dioxane, 0.05 mL). After stirring under a hydrogen balloon for 1 hour, the mixture was filtered and the filtrate was concentrated under reduced pressure to provide the product.

Workup

  1. filtrationthe mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customto provide the product

Sources & evidence

ORD record
ord-ee96471fa7de454ca5a3f170687a8075
Source dataset
uspto-grants-2015_08
Patent number
US09102639B2

Reaction notes

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