反应详情

N-[5-(3,5-Difluoro-benzoyl)-1-trityl-1H-indazol-3-yl]-2,2,2-trifluoro-acetamide (6.12 g, 10 mmol) was heated at 100° C. in a mixture isopropanol/tetrahydrofuran 8:2 (100 mL) and triethylamine (12.2 mL) for 48 hours. The volatiles were partially evaporated and the resulting mixture cooled and filtered. The solid was washed with diethyl ether. After drying under vacuum at 70° C. the title compound was obtained as a white solid (5.1 g, 99% yield).

1. customThe volatiles were partially evaporated
2. temperaturethe resulting mixture cooled
3. filtrationfiltered
4. washThe solid was washed with diethyl ether
5. dry with materialAfter drying under vacuum at 70° C. the title compound