Hydrochloric Acid → HCID 86647621, compound

HRID 512955Notes

Reaction equation

HRID 512955 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:46]=[C:47]([F:49])[CH:48]=1)[CH2:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[N:11](C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[N:10]=[C:9]2[NH:34][C:35](=[O:45])[C:36]1[CH:41]=[C:40]([CH:42]=[O:43])[CH:39]=[CH:38][C:37]=1[F:44].Cl>O1CCOCC1>[F:1][C:2]1[CH:3]=[C:4]([CH:46]=[C:47]([F:49])[CH:48]=1)[CH2:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][N:10]=[C:9]2[NH:34][C:35](=[O:45])[C:36]1[CH:41]=[C:40]([CH:42]=[O:43])[CH:39]=[CH:38][C:37]=1[F:44]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86647620HCID 86647620, compound

Product 1

HCID 86647621HCID 86647621, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

N-[5-(3,5-Difluoro-benzyl)-1-trityl-1H-indazol-3-yl]-2-fluoro-5-formyl-benzamide (740 mg, 1.137 mmol) in dry dioxan (25 mL) was treated with 4N HCl in dioxan (2.8 mL). The reaction was stirred at room temperature for two days. The volatile components were evaporated to dryness and the residue was taken up with Et2O (10 mL), stirred for 1 hour, filtered with suction, washed with Et2O (10 mL), dried at 50° C. under vacuum to afford 358 mg of title compound as a white solid in 77% yield.

Workup

  1. customThe volatile components were evaporated to dryness
  2. stirringstirred for 1 hour
  3. filtrationfiltered with suction
  4. washwashed with Et2O (10 mL)
  5. customdried at 50° C. under vacuum

Sources & evidence

ORD record
ord-9c1e663b2f2f442eb326c7fd66c42801
Source dataset
uspto-grants-2015_08
Patent number
US09102662B2

Reaction notes

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