Trimethylsilyldiazomethane → HCID 58216816, compound

HRID 513137Notes

Reaction equation

HRID 513137 reaction equation
[F:1][C:2]([F:11])([F:10])[CH:3]([CH2:8][CH3:9])[CH2:4][C:5]([OH:7])=[O:6].[CH3:12][Si](C=[N+]=[N-])(C)C>ClCCl.CO>[CH3:12][O:6][C:5](=[O:7])[CH2:4][CH:3]([C:2]([F:10])([F:11])[F:1])[CH2:8][CH3:9]

Participants

5

Reactant 2

HCID 167693TrimethylsilyldiazomethaneHCID 144070623-(Trifluoromethyl)pentanoic acid

Product 1

HCID 58216816HCID 58216816, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of Example 1D (250 mg, 1.47 mmol) in dichloromethane (10 mL) and methanol (0.25 mL), under nitrogen atmosphere, trimethylsilyldiazomethane (2.0 M solution in diethyl ether) (2.1 mL, 4.19 mmol) was added drop wise at 0° C.

Sources & evidence

ORD record
ord-3137da8228fe4cc88c9958534f0a98c6
Source dataset
uspto-grants-2015_08
Patent number
US09102679B2

Reaction notes

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