Sulfuric Acid → 6-Bromo-7-methoxyindoline-2,3-dione

HRID 513232Notes

Reaction equation

HRID 513232 reaction equation
[Br:1][C:2]1[C:3]([O:14][CH3:15])=[C:4]([NH:8][C:9](=[O:13])[CH:10]=NO)[CH:5]=[CH:6][CH:7]=1.[OH:16]S(O)(=O)=O>>[Br:1][C:2]1[C:3]([O:14][CH3:15])=[C:4]2[C:5]([C:10](=[O:16])[C:9](=[O:13])[NH:8]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 131733281N-(3-Bromo-2-methoxy-phenyl)-2-hydroxyimino-acetamide

Product 1

HCID 1175999946-Bromo-7-methoxyindoline-2,3-dione

Procedure

A mixture of N-(3-Bromo-2-methoxy-phenyl)-2-hydroxyimino-acetamide (36 g, 0.132 mol), conc.H2SO4 (193 mL) is stirred at 80° C. for 1 hour. After reaction, poured the reaction mixture into ice water (2 L). The mixture is filtered and the solid is dried under vacuum to give the desired product.

Workup

  1. customAfter reaction
  2. filtrationThe mixture is filtered
  3. customthe solid is dried under vacuum

Sources & evidence

ORD record
ord-33df2617ebfe4ce681dd40ff3d63c20d
Source dataset
uspto-grants-2015_08
Patent number
US09102684B2

Reaction notes

Loading…