HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 513235Generated: October 30, 2026
Hydrochloric Acid → N-(3-bromo-2-methylphenyl)-2-(hydroxyimino)acetamide
https://huagongshe.com/reaction/513235
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Chloral Hydrate | HCID 2707 | — |
| Reactant | Sodium Sulfate | HCID 24436 | — |
| Reactant | 3-Bromo-o-toluidine | HCID 123538 | — |
| Reactant | Hydroxylamine, sulfate (1:1) | HCID 159255 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-(3-bromo-2-methylphenyl)-2-(hydroxyimino)acetamide | HCID 72595240 | — |
Reaction Steps
A mixture of 3-Bromo-2-methyl-phenylamine (15.6 g, 0.084 mol), NH2OH H2SO4 (71.25 g, 0.5 mol), conc. HCl (8.8 mL) in H2O (90 mL) is slowly added to a solution of chloral hydrate (15.2 g, 0.09 mol), Na2SO4 (71.25 g, 0.44 mol) in H2O (255 mL) then stirred at 35° C. for 1 h, 52° C. for 1.5 h, 75° C. for 1 h. After the reaction, the mixture is filtered and the solid is dried under vacuum to give product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09102684B2 |
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| Source dataset | uspto-grants-2015_08 |
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| ORD ID | ord-e948ff0011294baaa4103f6f9d16b35b |
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| Source note | uspto-grants-2015_08 |
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