反应详情

温度

75 °C

A mixture of 3-Bromo-2-methyl-phenylamine (15.6 g, 0.084 mol), NH2OH H2SO4 (71.25 g, 0.5 mol), conc. HCl (8.8 mL) in H2O (90 mL) is slowly added to a solution of chloral hydrate (15.2 g, 0.09 mol), Na2SO4 (71.25 g, 0.44 mol) in H2O (255 mL) then stirred at 35° C. for 1 h, 52° C. for 1.5 h, 75° C. for 1 h. After the reaction, the mixture is filtered and the solid is dried under vacuum to give product.

1. customAfter the reaction
2. filtrationthe mixture is filtered
3. customthe solid is dried under vacuum
4. customto give product