Hydrogen Peroxide → 2-Amino-4-bromo-3-methylbenzoic acid

HRID 513237Notes

Reaction equation

HRID 513237 reaction equation
[OH:1]O.[Br:3][C:4]1[C:12]([CH3:13])=[C:11]2[C:7]([C:8](=[O:15])C(=O)[NH:10]2)=[CH:6][CH:5]=1.[OH-].[Na+]>O>[NH2:10][C:11]1[C:12]([CH3:13])=[C:4]([Br:3])[CH:5]=[CH:6][C:7]=1[C:8]([OH:15])=[O:1]

Participants

5

Reactant 3

HCID 784Hydrogen PeroxideHCID 14798Sodium HydroxideHCID 112301886-Bromo-7-methyl-1H-indole-2,3-dione

Product 1

HCID 148855482-Amino-4-bromo-3-methylbenzoic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

H2O2 (37%, 9.5 mL, 0.075 mol) in H2O (83 mL) is slowly added to a solution of 6-Bromo-7-methyl-1H-indole-2,3-dione (8.4 g, 0.035 mol) and NaOH (9.6 g, 0.24 mol) in H2O (185 mL) then stirred at room temperature for 1 h, After reaction, the mixture is filtered and the solid is dried under vacuum to give product.

Workup

  1. customAfter reaction
  2. filtrationthe mixture is filtered
  3. customthe solid is dried under vacuum
  4. customto give product

Sources & evidence

ORD record
ord-25826555878c46f1924d5064d961cb24
Source dataset
uspto-grants-2015_08
Patent number
US09102684B2

Reaction notes

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