HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → HCID 86664547, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | 8-Hydroxyquinoline | HCID 1923 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 6-Chloro-4-(3-iodobenzylamino)nicotinamide | HCID 86664546 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 86664547 | HCID 86664547 | 51% |
Reaction Steps
A mixture of 6-chloro-4-(3-iodobenzylamino)nicotinamide (130 mg, 0.335 mmol), imidazole (30 mg, 0.441 mmol), 8-hydroxyquinoline (15 mg, 0.103 mmol), K2CO3 (60 mg, 0.434 mmol) and CuI (15 mg, 0.078 mmol) in DMSO (1 mL) was degassed with Ar, then was stirred at 130 C for 2 h. The mixture was purified by HPLC to give 4-(3-(1H-imidazol-1-yl)benzylamino)-6-chloronicotinamide (56 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102625B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-864fd7f4707248a592d9d5574e4af434 |
| Source note | uspto-grants-2015_08 |