反应详情

A mixture of 6-chloro-4-(3-iodobenzylamino)nicotinamide (130 mg, 0.335 mmol), imidazole (30 mg, 0.441 mmol), 8-hydroxyquinoline (15 mg, 0.103 mmol), K2CO3 (60 mg, 0.434 mmol) and CuI (15 mg, 0.078 mmol) in DMSO (1 mL) was degassed with Ar, then was stirred at 130 C for 2 h. The mixture was purified by HPLC to give 4-(3-(1H-imidazol-1-yl)benzylamino)-6-chloronicotinamide (56 mg).

1. customwas degassed with Ar
2. customThe mixture was purified by HPLC