反应详情

温度

130 °C

Phosphorus pentachloride (3.0 g, 14.6 mmol) was added to a solution of 3-pyridinesulfonic acid (1.5 g, 9.42 mmol) dissolved in phosphoryl trichloride (2.45 g, 16.0 mmol) and the mixture heated to 130° C. for 3 h under argon. The mixture was concentrated in vacuo, the residue was quenched over ice and extracted with ether. The organic phase was washed with a saturated sodium bicarbonate solution and concentrated in vacuo to give the crude title compound (0.6 g, 36%) which was used immediately without purification.

1. concentrationThe mixture was concentrated in vacuo
2. customthe residue was quenched over ice
3. extractionextracted with ether
4. washThe organic phase was washed with a saturated sodium bicarbonate solution
5. concentrationconcentrated in vacuo