反应详情

温度

122 °C

47% HBr (10 ml) was added to 8-methoxy-3-methylquinoline (Intermediate 29) (500 mg, 2.80 mmol) and heated at 122° C. for 18 h. The reaction was cooled to room temperature, the pH adjusted with sodium carbonate solution to pH=7 and extracted with DCM. The organic phase was dried (Na2SO4) and concentrated in vacuo to give the title compound (150 mg, 83%).

1. temperatureThe reaction was cooled to room temperature
2. extractionextracted with DCM
3. dry with materialThe organic phase was dried (Na2SO4)
4. concentrationconcentrated in vacuo