HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous Chloride → 6-(Trifluoromethoxy)quinolin-8-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 8-Nitro-6-(trifluoromethoxy)quinolone | HCID 86669755 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Product | 6-(Trifluoromethoxy)quinolin-8-amine | HCID 68183001 | 84.4% |
Reaction Steps
In a similar fashion using route 1 general procedure 4, 8-nitro-6-(trifluoromethoxy)quinolone (Intermediate 34) (1.1 g, 4.26 mmol), tin (II) chloride (2.42 g, 12.8 mmol) and 6 N HCl (13 drops) gave the title compound (820 mg, 84%) which was used in the next step without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-21318f5fd3394da6869a56505f1ad65e |
| Source note | uspto-grants-2015_08 |