HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous Chloride → 5-Fluoroquinolin-8-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 5-Fluoro-8-nitroquinoline | HCID 153972 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Product | 5-Fluoroquinolin-8-amine | HCID 44558264 | 106.7% |
Reaction Steps
In a similar fashion using route 1 general procedure 4, 5-fluoro-8-nitroquinoline (Intermediate 38) (500 mg, 2.60 mmol), tin (II) chloride (1.48 mg, 7.80 mmol) and 6N HCl (4 drops) gave the title compound (450 mg, >100% crude) which was used in the next step without purification. The structure was confirmed by 1H NMR.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-298ae85fea2e40198d3e3363f146e7b2 |
| Source note | uspto-grants-2015_08 |