Sulfuric Acid → HCID 12363388, compound

HRID 513411Notes

Reaction equation

HRID 513411 reaction equation
[CH2:1]([C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1)[CH3:2].[N+:13]([O-])([O-:15])=[O:14].[K+].OS(O)(=O)=O>>[CH2:1]([C:3]1[C:12]([N+:13]([O-:15])=[O:14])=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1)[CH3:2]

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 243117-Ethylquinoline2×HCID 24434Potassium Nitrate

Product 1

HCID 12363388HCID 12363388, compoundYield 12%

Procedure

In a similar fashion using route 7 general procedure 15, 7-ethylquinoline (Intermediate 57) (1.21 g, 7.7 mmol), potassium nitrate (1.01 g, 10.0 mmol) and H2SO4 (3.6 ml) gave the title compound (170 mg, 12%) after purification by column chromatography with n-hexane/EtOAc (23:2-17:3) gradient elution.

Sources & evidence

ORD record
ord-fa312705a4f942b289e5c8d665c0b0d8
Source dataset
uspto-grants-2015_08
Patent number
US09102688B2

Reaction notes

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