Stannous Chloride → HCID 68183445, compound

HRID 513414Notes

Reaction equation

HRID 513414 reaction equation
[CH2:1]([C:3]1[C:12]([N+:13]([O-])=O)=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1)[CH3:2].[Sn](Cl)Cl>Cl>[CH2:1]([C:3]1[C:12]([NH2:13])=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1)[CH3:2]

Participants

4

Reactant 2

HCID 24479Stannous ChlorideHCID 12363388HCID 12363388, compound2×

Product 1

HCID 68183445HCID 68183445, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidCatalyst

Procedure

In a similar fashion using route 1 general procedure 4, 7-ethyl-8-nitroquinoline (Intermediate 60) (170 mg, 0.84 mmol), tin (II) chloride (500 mg, 2.52 mmol) and 6 N HCl (2 drops) gave the title compound (144 mg, 100%) which was used in the next step without purification.

Sources & evidence

ORD record
ord-e1f096c4f7884d6f9d5264308159e50b
Source dataset
uspto-grants-2015_08
Patent number
US09102688B2

Reaction notes

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