反应详情

Fuming nitric acid (8 ml) and concentrated sulfuric acid (16 ml) were combined cautiously at −10° C. 4,7-dichloroquinoline (5 g, 25 mmol) was added portionwise at −10° C. and after complete addition the mixture was allowed to warm to room temperature and stirring continued for 18 h. The reaction mixture was poured onto ice and the resulting solid removed by filtration washed with water (100 ml) to give the title compound (5.7 g, 94%).

1. customwere combined cautiously at −10° C
2. additionafter complete addition the mixture
3. additionThe reaction mixture was poured onto ice
4. customthe resulting solid removed by filtration
5. washwashed with water (100 ml)