7-Chloro-4-methoxy-8-nitro-quinoline → 7-Chloro-4-methoxyquinolin-8-amine

HRID 513421ノート

反応式

HRID 513421 の反応式
[Cl:1][C:2]1[C:11]([N+:12]([O-])=O)=[C:10]2[C:5]([C:6]([O:15][CH3:16])=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1>[Pd].CCO>[Cl:1][C:2]1[C:11]([NH2:12])=[C:10]2[C:5]([C:6]([O:15][CH3:16])=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1

参加物

4

反応物 1

HCID 681834397-Chloro-4-methoxy-8-nitro-quinoline2 回

生成物 1

HCID 681832377-Chloro-4-methoxyquinolin-8-amine収率 107.2%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

7-Chloro-4-methoxy-8-nitro-quinoline (Intermediate 69) (261 mg, 1.1 mmol) was treated with 10% palladium on carbon (11.6 mg, cat) in EtOH (20 ml) in a Parr pressure reaction system and placed under a hydrogen atmosphere at 5 Barr pressure whilst stirring overnight. The pressure was released and the catalyst removed by filtration through celite. The solvent was removed in vacuo to give the title compound (246 mg, 100%).

後処理

  1. customthe catalyst removed by filtration through celite
  2. customThe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-6fb5f34f3b7c420994def6d68139fd9f
出典データセット
uspto-grants-2015_08
特許番号
US09102688B2

反応ノート

読み込み中…