反应详情

10% palladium on carbon (125 mg, 1.1 mmol) was added to a solution of 7-chloro-4-methoxy-quinolin-8-ylamine (Intermediate 70) (246 mg, 1.1 mmol), and ammonium formate (365 mg, 5.8 mmol) in 50% acetic acid (5 ml) and the reaction was heated under reflux for 30 min. After cooling the solvent was removed in vacuo. The residue was dissolved in EtOAc (100 ml) and washed with sat sodium bicarbonate solution, dried (MgSO4) and concentrated in vacuo to give the title compound (124 mg, 65%).

1. temperaturethe reaction was heated
2. temperatureunder reflux for 30 min
3. temperatureAfter cooling the solvent
4. customwas removed in vacuo
5. dissolutionThe residue was dissolved in EtOAc (100 ml)
6. washwashed
7. dry with materialdried (MgSO4)
8. concentrationconcentrated in vacuo