5-Chloroquinolin-8-amine → 4-Chloro-N-(5-chloro-quinolin-8-yl)-2-fluoro-benzenesulfonamide

反応式

[Cl:1][C:2]1[CH:11]=[CH:10][C:9]([NH2:12])=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([S:20](Cl)(=[O:22])=[O:21])=[C:16]([F:24])[CH:15]=1>>[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([NH:12][C:9]2[CH:10]=[CH:11][C:2]([Cl:1])=[C:3]3[C:8]=2[N:7]=[CH:6][CH:5]=[CH:4]3)(=[O:21])=[O:22])=[C:16]([F:24])[CH:15]=1

参加物

反応物 2

HCID 2248605-Chloroquinolin-8-amine2 回

HCID 27788604-Chloro-2-fluorobenzene-1-sulfonyl chloride

生成物 1

HCID 601639224-Chloro-N-(5-chloro-quinolin-8-yl)-2-fluoro-benzenesulfonamide収率 35%

実験手順

In a similar fashion using route 14 general procedure 26, 5-chloroquinolin-8-amine (Intermediate 27) (50 mg, 0.28 mmol), 4-chloro-2-fluorobenzenesulfonyl chloride (96 mg, 0.42 mmol) gave the title compound (35 mg, 35%) after purification by column chromatography with DCM as the eluent.

出典と根拠

ORDレコード: ord-6d2e37482ef94f8489eeaf433c6f81c7
出典データセット: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09102688B2

反応ノート

読み込み中…