HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloroquinolin-8-amine → 4-Chloro-N-(5-chloro-quinolin-8-yl)-2-fluoro-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloroquinolin-8-amine | HCID 224860 | — |
| Reactant | 4-Chloro-2-fluorobenzene-1-sulfonyl chloride | HCID 2778860 | — |
| Product | 4-Chloro-N-(5-chloro-quinolin-8-yl)-2-fluoro-benzenesulfonamide | HCID 60163922 | 35% |
Reaction Steps
In a similar fashion using route 14 general procedure 26, 5-chloroquinolin-8-amine (Intermediate 27) (50 mg, 0.28 mmol), 4-chloro-2-fluorobenzenesulfonyl chloride (96 mg, 0.42 mmol) gave the title compound (35 mg, 35%) after purification by column chromatography with DCM as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-6d2e37482ef94f8489eeaf433c6f81c7 |
| Source note | uspto-grants-2015_08 |