HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-Aminoquinoline → N-(quinolin-8-yl)-2-(trifluoromethoxy)benzene-1-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-Aminoquinoline | HCID 11359 | — |
| Reactant | 2-(Trifluoromethoxy)benzene-1-sulfonyl chloride | HCID 2777215 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | N-(quinolin-8-yl)-2-(trifluoromethoxy)benzene-1-sulfonamide | HCID 17501753 | 60% |
Reaction Steps
In the similar fashion using route 14 general procedure 27, 8-aminoquinoline (100 mg, 0.69 mmol), 2-trifluoromethoxybenzenesulfonyl chloride (200 mg, 0.69 mmol) and DMAP (cat.) gave the title compound (150 mg, 60%) after column purification with DCM elution.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-10a29906df2d445c8b009382405375b2 |
| Source note | uspto-grants-2015_08 |