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HRID513446

反应详情

EQUATION

反应方程式

HRID 513446 的结构方程式

REACTANTS

反应物

2
结构：Nc1cccc2cccnc12
HCID11359

8-Quinolinamine

C9H8N2

结构：O=S(=O)(Cl)c1ccccc1OC(F)(F)F
HCID2777215

2-(Trifluoromethoxy)benzenesulfonyl chloride

C7H4ClF3O3S

PRODUCTS

生成物

1
结构：O=S(=O)(Nc1cccc2cccnc12)c1ccccc1OC(F)(F)F
HCID17501753

未命名化合物

收率 60%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)c1ccncc1
催化剂HCID14284

N,N-Dimethylpyridin-4-amine

C7H10N2

PROCEDURE

实验过程

In the similar fashion using route 14 general procedure 27, 8-aminoquinoline (100 mg, 0.69 mmol), 2-trifluoromethoxybenzenesulfonyl chloride (200 mg, 0.69 mmol) and DMAP (cat.) gave the title compound (150 mg, 60%) after column purification with DCM elution.