HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-Aminoquinoline → 3-(Quinolin-8-ylsulfamoyl)-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-Aminoquinoline | HCID 11359 | — |
| Reactant | Benzoic acid, 3-(chlorosulfonyl)-, methyl ester | HCID 113339 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | 3-(Quinolin-8-ylsulfamoyl)-benzoic acid methyl ester | HCID 31702993 | 64% |
Reaction Steps
In the similar fashion using route 14 general procedure 27, 8-aminoquinoline (100 mg, 0.69 mmol), methyl 3-chlorosulfonylbenzoate (160 mg, 0.69 mmol) and DMAP (cat.) gave the title compound (150 mg, 64%) after purification by column chromatography with DCM as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-8dee330c2dd447c49a029927665986ad |
| Source note | uspto-grants-2015_08 |