HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Benzenesulfonyl chloride → N-(7-Methylquinolin-8-yl)-benzenesulfonamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Benzenesulfonyl chloride | HCID 7369 | — |
| Edukt | 8-Quinolinamine, 7-methyl- | HCID 231556 | — |
| Katalysator | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Produkt | N-(7-Methylquinolin-8-yl)-benzenesulfonamide | HCID 60163754 | 67% |
Reaktionsschritte
In the similar fashion using route 14 general procedure 27, 7-methyl-8-aminoquinoline (200 mg, 1.26 mmol), benzenesulfonyl chloride (260 mg, 1.5 mmol) and DMAP (cat.) gave the title compound (250 mg, 67%) after purification by column chromatography with DCM as the eluent.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09102688B2 |
| Quelldatensatz | uspto-grants-2015_08 |
| ORD ID | ord-af0ab3da6d054caba4d08b086446fa9c |
| Quellennotiz | uspto-grants-2015_08 |