HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Difluorobenzenesulfonyl chloride → 2,6-Difluoro-N-(6-fluoro-quinolin-8-yl)-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Difluorobenzenesulfonyl chloride | HCID 2734271 | — |
| Reactant | 6-Fluoroquinolin-8-amine | HCID 13227992 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | 2,6-Difluoro-N-(6-fluoro-quinolin-8-yl)-benzenesulfonamide | HCID 68183393 | 55% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, 6-fluoroquinolin-8-amine (Intermediate 48) (140 mg, 0.86 mmol), 2,6-difluorobenzenesulfonyl chloride (220 mg, 1.04 mmol) and DMAP (cat.) gave the title compound (160 mg, 55%) after purification by column chromatography with DCM as the eluent followed by recrystallisation with DCM/n-pentane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-51575ae4fef84c0d841afb858b663333 |
| Source note | uspto-grants-2015_08 |