反应详情

In a similar fashion using route 14 general procedure 27, 6-fluoroquinolin-8-amine (Intermediate 48) (140 mg, 0.86 mmol), 2,6-difluorobenzenesulfonyl chloride (220 mg, 1.04 mmol) and DMAP (cat.) gave the title compound (160 mg, 55%) after purification by column chromatography with DCM as the eluent followed by recrystallisation with DCM/n-pentane.