HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine-3-sulfonyl chloride → Pyridine-3-sulfonic acid (6-fluoro-quinolin-8-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine-3-sulfonyl chloride | HCID 3164136 | — |
| Reactant | 6-Fluoroquinolin-8-amine | HCID 13227992 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | Pyridine-3-sulfonic acid (6-fluoro-quinolin-8-yl)-amide | HCID 68190277 | 32% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, 6-fluoroquinolin-8-amine (Intermediate 48) (100 mg, 0.62 mmol), pyridine 3-sulfonyl chloride (Intermediate 17) (130 mg, 0.74 mmol) and DMAP (cat.) gave the title compound (60 mg, 32%) after purification by column chromatography with n-hexane/DCM (1:0-0:1) gradient elution followed by recrystallisation from DCM/n-pentane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-94d81bddf56844818be10c2c84de5ff7 |
| Source note | uspto-grants-2015_08 |