反应详情

In a similar fashion using route 14 general procedure 27, 6-fluoroquinolin-8-amine (Intermediate 48) (100 mg, 0.62 mmol), pyridine 3-sulfonyl chloride (Intermediate 17) (130 mg, 0.74 mmol) and DMAP (cat.) gave the title compound (60 mg, 32%) after purification by column chromatography with n-hexane/DCM (1:0-0:1) gradient elution followed by recrystallisation from DCM/n-pentane.