HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenesulfonyl chloride → N-(5-Fluoro-quinolin-8-yl)-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenesulfonyl chloride | HCID 7369 | — |
| Reactant | 5-Fluoroquinolin-8-amine | HCID 44558264 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(5-Fluoro-quinolin-8-yl)-benzenesulfonamide | HCID 68183232 | 61% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, 5-fluoroquinolin-8-amine (Intermediate 50) (150 mg, 0.93 mmol), benzenesulfonyl chloride (196 mg, 1.11 mmol) and DMAP (cat) gave the title compound (170 mg, 61%) after column chromatography with DCM eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-4ea9514860864082ba9396f0c178abf3 |
| Source note | uspto-grants-2015_08 |