HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 6-Trifluoromethyl-pyridine-3-sulfonic acid (6-fluoro-quinolin-8-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 6-Fluoroquinolin-8-amine | HCID 13227992 | — |
| Reactant | 6-(Trifluoromethyl)pyridine-3-sulfonyl chloride | HCID 45594311 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 6-Trifluoromethyl-pyridine-3-sulfonic acid (6-fluoro-quinolin-8-yl)-amide | HCID 60164189 | 26.3% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, 6-fluoroquinolin-8-ylamine (Intermediate 48) (150 mg, 0.92 mmol), 6-(trifluoromethyl)pyridine-3-sulfonyl chloride (250 mg, 1.01 mmol) in DCM (2 ml), DMAP (cat), pyridine (146 mg, 1.84 mmol) and DCM (5 ml) gave the title compound (90 mg, 26%) after purification by column chromatography with n-hexane/EtOAc (90:10) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-2b98fa839d7e4d83a2e86d2e1b803c59 |
| Source note | uspto-grants-2015_08 |