反应详情

In a similar fashion using route 14 general procedure 27, 6-fluoroquinolin-8-ylamine (Intermediate 48) (150 mg, 0.92 mmol), 6-(trifluoromethyl)pyridine-3-sulfonyl chloride (250 mg, 1.01 mmol) in DCM (2 ml), DMAP (cat), pyridine (146 mg, 1.84 mmol) and DCM (5 ml) gave the title compound (90 mg, 26%) after purification by column chromatography with n-hexane/EtOAc (90:10) as the eluent.