HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 5-Methyl-pyridine-2-sulfonic acid quinolin-8-ylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 5-Methylpyridine-2-sulfonyl chloride | HCID 12295463 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Methyl-pyridine-2-sulfonic acid quinolin-8-ylamide | HCID 68183382 | 25% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, 8-aminoqunoline (40 mg, 0.27 mmol), 5-methyl-pyridine-2-sulfonyl chloride 440 (79 mg, 0.41 mmol), pyridine (1.5 ml) DMAP (cat.) and DCM (2 ml) gave the title compound (21 mg, 25%) after purification by column chromatography with n-hexane/EtOAc (93:7) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-311fe6dc3e554d51b0a165ecd488016c |
| Source note | uspto-grants-2015_08 |