反应详情

In a similar fashion using route 14 general procedure 27, 8-aminoqunoline (250 mg, 1.73 mmol), thiazole-2-sulfonyl chloride (Intermediate 444) (413 mg, 2.25 mmol), pyridine (2 ml), DMAP (cat.) and DCM (2 ml) gave the title compound (110 mg, 15%), after purification by column chromatography with n-hexane/EtOAc (90:10) as the eluent.