反应详情

In a similar fashion using route 14 general procedure 27, 6-trifluoromethoxy-quinolin-8-ylamine (Intermediate 46) (110 mg, 0.48 mmol), pyridine-2-sulfonyl chloride (Intermediate 18) (102 mg, 0.57 mmol), pyridine (0.08 ml, 0.96 mmol), DMAP (cat.) and DCM (5 ml) gave the title compound (100 mg, 56%) after purification by column chromatography with n-hexane/DCM (50:50) as the eluent.