HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 6-Cyano-pyridine-3-sulfonic acid (6-trifluoromethoxy-quinolin-8-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 6-Cyanopyridine-3-sulfonyl chloride | HCID 47003190 | — |
| Reactant | 6-(Trifluoromethoxy)quinolin-8-amine | HCID 68183001 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 6-Cyano-pyridine-3-sulfonic acid (6-trifluoromethoxy-quinolin-8-yl)-amide | HCID 60164305 | 35.2% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, 6-(trifluoromethoxy)quinolin-8-ylamine (Intermediate 46) (125 mg, 0.54 mmol), 6-cyano-pyridine-3-sulfonyl chloride (Intermediate 19) (132 mg, 0.65 mmol), pyridine (0.09 ml, 1.09 mmol), DMAP (cat.) and DCM (10 ml) gave the title compound (75 mg, 35%) after purification by column chromatography with n-hexane/DCM (50:50) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-7453ca1b61634487825b91a15b7ff0cb |
| Source note | uspto-grants-2015_08 |