反应详情

In a similar fashion using route 14 general procedure 27, 6-(trifluoromethoxy)quinolin-8-ylamine (Intermediate 46) (125 mg, 0.54 mmol), 6-cyano-pyridine-3-sulfonyl chloride (Intermediate 19) (132 mg, 0.65 mmol), pyridine (0.09 ml, 1.09 mmol), DMAP (cat.) and DCM (10 ml) gave the title compound (75 mg, 35%) after purification by column chromatography with n-hexane/DCM (50:50) as the eluent.