HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxy-2-nitrobenzenesulphonyl chloride → 2-Nitro-4-methoxy-N-(2-methyl-quinolin-8-yl)-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxy-2-nitrobenzenesulphonyl chloride | HCID 87452 | — |
| Reactant | 2-Methyl-8-aminoquinoline | HCID 140457 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | 2-Nitro-4-methoxy-N-(2-methyl-quinolin-8-yl)-benzenesulfonamide | HCID 23631949 | 51.8% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, 2-methyl-quinolin-8-ylamine (Intermediate 22) (500 mg, 3.1 mmol) and 4-methoxy-2-nitrobenzenesulfonyl chloride (826 mg, 3.4 mmol) and DMAP (19 mg, 1.5 mmol) gave the title compound (600 mg, 51%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-64139ef3c8ba40929d663ea8f85cacbf |
| Source note | uspto-grants-2015_08 |