Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Nitro-p-toluenesulphonyl chloride → N-(5-chloroquinolin-8-yl)-4-methyl-2-nitrobenzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Nitro-p-toluenesulphonyl chloride | HCID 104689 | — |
| 반응물 | 5-Chloroquinolin-8-amine | HCID 224860 | — |
| 생성물 | N-(5-chloroquinolin-8-yl)-4-methyl-2-nitrobenzenesulfonamide | HCID 68183028 | 54% |
반응 단계
In a similar fashion using route 14 general procedure 26, 5-chloro-8-aminoquinoline (Intermediate 27) (150 mg, 0.84 mmol), 2-nitro-4-methylbenzenesulfonyl chloride (Intermediate 20) (228 mg, 1.26 mmol) gave the title compound (170 mg, 54%) after purification by column chromatography with DCM as the eluent.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09102688B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-f04db447f47e4542906d65fcf31e2fdf |
| 출처 메모 | uspto-grants-2015_08 |