HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Pyridine → N-(5-Fluoro-quinolin-8-yl)-2-nitro-benzenesulfonamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Pyridine | HCID 1049 | — |
| Edukt | 2-Nitrobenzenesulfonyl chloride | HCID 15540 | — |
| Edukt | 5-Fluoroquinolin-8-amine | HCID 44558264 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | N-(5-Fluoro-quinolin-8-yl)-2-nitro-benzenesulfonamide | HCID 68183367 | 67,7% |
Reaktionsschritte
In a similar fashion using route 14 general procedure 26, 5-fluoro-quinolin-8-ylamine (Intermediate 50) (350 mg, 2.0 mmol), 2-nitro-benzenesulfonyl chloride (575 mg, 2.59 mmol), pyridine (0.35 ml, 4.3 mmol) and DCM (12 ml) gave the title compound (470 mg, 63%) after purification by column chromatography with DCM as the eluent.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09102688B2 |
| Quelldatensatz | uspto-grants-2015_08 |
| ORD ID | ord-22dbaf74ce644371975ac73fdc4a6b1e |
| Quellennotiz | uspto-grants-2015_08 |