HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → N-(5-Fluoro-quinolin-8-yl)-2-nitro-4-trifluoromethyl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 2-Nitro-4-(trifluoromethyl)benzene-1-sulfonyl chloride | HCID 2775780 | — |
| Reactant | 5-Fluoroquinolin-8-amine | HCID 44558264 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(5-Fluoro-quinolin-8-yl)-2-nitro-4-trifluoromethyl-benzenesulfonamide | HCID 68183389 | 59% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, 5-fluoro-quinolin-8-ylamine (Intermediate 50) (280 mg, 1.73 mmol), 2-nitro-4-trifluoromethylbenzenesulfonyl chloride (0.6 g, 2.07 mmol), DMAP (cat), pyridine (0.42 ml, 5.19 mmol) and DCM (5 ml) gave the title compound (420 mg, 59%) after purification by column chromatography with DCM/MeOH (98:2) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-45747c34636241a6a311f94a69d0f8bf |
| Source note | uspto-grants-2015_08 |