反应详情

In a similar fashion using route 14 general procedure 27, 5-fluoro-quinolin-8-ylamine (Intermediate 50) (280 mg, 1.73 mmol), 2-nitro-4-trifluoromethylbenzenesulfonyl chloride (0.6 g, 2.07 mmol), DMAP (cat), pyridine (0.42 ml, 5.19 mmol) and DCM (5 ml) gave the title compound (420 mg, 59%) after purification by column chromatography with DCM/MeOH (98:2) as the eluent.