反应详情

In a similar fashion using route 14 general procedure 27, 4-trifluoromethyl-quinolin-8-ylamine (Intermediate 469) (350 mg, 1.65 mmol), 2-nitrobenzenesulfonyl chloride (474 mg, 12.1 mmol), DMAP (cat), pyridine (2 ml) and DCM (5 ml) gave the title compound (400 mg, 60%) after purification by column chromatography with n-hexane/EtOAc (80:20) as the eluent.