HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 4-Chloro-2-nitro-N-quinolin-8-yl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 8-Aminoquinoline | HCID 11359 | — |
| Reactant | 4-Chloro-2-nitrophenylsulfonyl chloride | HCID 20631 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Chloro-2-nitro-N-quinolin-8-yl-benzenesulfonamide | HCID 23631958 | 26.5% |
Reaction Steps
In a similar fashion using route 18 general procedure 27, 8-aminoquinoline (420 mg, 2.91 mmol), 4-chloro-2-nitro-benzenesulfonyl chloride (Intermediate 454) (1.1 g, 4.37 mmol), pyridine (1.5 ml), DMAP (cat.) and DCM (10 ml) gave the title compound (280 mg, 16%) after purification by column chromatography with n-hexane/EtOAc (90:10) elution.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-af73bcfaf5cd4dc6a2c8a695d65511fe |
| Source note | uspto-grants-2015_08 |