反应详情

In a similar fashion using route 18 general procedure 27, 8-aminoquinoline (420 mg, 2.91 mmol), 4-chloro-2-nitro-benzenesulfonyl chloride (Intermediate 454) (1.1 g, 4.37 mmol), pyridine (1.5 ml), DMAP (cat.) and DCM (10 ml) gave the title compound (280 mg, 16%) after purification by column chromatography with n-hexane/EtOAc (90:10) elution.