HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 4-Fluoro-5-methyl-2-nitro-N-quinolin-8-yl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 8-Aminoquinoline | HCID 11359 | — |
| Reactant | 4-Fluoro-5-methyl-2-nitro-benzenesulfonyl chloride | HCID 86669759 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Fluoro-5-methyl-2-nitro-N-quinolin-8-yl-benzenesulfonamide | HCID 68183290 | 52% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, 4-fluoro-5-methyl-2-nitro-benzenesulfonyl chloride (Intermediate 452) (1.6 g, 6.3 mmol), 8-aminoquinoline (700 mg, 4.86 mmol), DMAP (cat.), pyridine (5 ml) and DCM (5 ml) gave the title compound (520 mg, 52%) after purification by column chromatography with DCM/MeOH (99:1) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-fc01fb4d4bd043589581b74e5a82436a |
| Source note | uspto-grants-2015_08 |